Protein Name 3-hydroxyanthranilate 3,4-dioxygenase
Organism Homo sapiens
Gene ID 23498
Gene Symbol

HAAO

UniProt P46952 (3HAO_HUMAN)
Relationships Total Number of functionally related compound(s) : 46
Total Number of Articles : 42
Description

3-hydroxyanthranilate 3,4-dioxygenase

Gene Summary

3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]

synonyms
  • 3-hydroxyanthranilate 3,4-dioxygenase
  • 3-hydroxyanthranilate oxygenase
  • 3-hydroxyanthranilic acid dioxygenase
Click to show/hide the synonyms
Properties