Protein Name POU domain, class 1, transcription factor 1
Organism Mus musculus
Gene ID 18736
Gene Symbol

Pou1f1

UniProt Q00286 (PIT1_MOUSE)
Relationships Total Number of functionally related compound(s) : 39
Total Number of Articles : 35
Description

POU domain, class 1, transcription factor 1

Gene Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding activity; and sequence-specific DNA binding activity. Acts upstream of or within several processes, including determination of adult lifespan; positive regulation of biosynthetic process; and somatotropin secreting cell development. Located in nucleus. Is expressed in several structures, including central nervous system; eye; genitourinary system; and trunk somite. Human ortholog(s) of this gene implicated in combined or isolated pituitary hormone deficiency 1 and pituitary gland disease. Orthologous to human POU1F1 (POU class 1 homeobox 1). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • pituitary-specific positive transcription factor 1
  • POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)
  • pituitary specific transcription factor 1, related sequence 1
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Properties