Protein Name acid phosphatase 2, lysosomal
Organism Homo sapiens
Gene ID 53
Gene Symbol


UniProt P11117 (PPAL_HUMAN), B7Z7D2 (B7Z7D2_HUMAN), E9PHY0 (E9PHY0_HUMAN), E9PQY3 (E9PQY3_HUMAN), B7Z6T8 (B7Z6T8_HUMAN), B7Z8T9 (B7Z8T9_HUMAN), B7Z6L8 (B7Z6L8_HUMAN), B7Z4Z2 (B7Z4Z2_HUMAN), B7Z552 (B7Z552_HUMAN)
Relationships Total Number of functionally related compound(s) : 41
Total Number of Articles : 20

acid phosphatase 2, lysosomal

Gene Summary

The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017]

  • lysosomal acid phosphatase
  • LAP
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