| Protein Name | trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase MIS1 |
|---|---|
| Organism | Saccharomyces cerevisiae S288C |
| Gene ID | 852378 |
| Gene Symbol | MIS1 |
| UniProt | P09440 (C1TM_YEAST) |
| Relationships |
Total Number of functionally related compound(s) :
5
Total Number of Articles : 3 |
Description |
trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase MIS1 |
| Gene Summary |
Enables formate-tetrahydrofolate ligase activity; methenyltetrahydrofolate cyclohydrolase activity; and methylenetetrahydrofolate dehydrogenase (NADP+) activity. Involved in folic acid biosynthetic process and nucleobase-containing compound metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; abdominal aortic aneurysm; cleft lip; developmental cardiac valvular defect; and neural tube defect (multiple). Orthologous to human MTHFD1L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like) and MTHFD1 (methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |