| Protein Name | LPS responsive beige-like anchor protein |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 987 |
| Gene Symbol | LRBA |
| UniProt | P50851 (LRBA_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
47
Total Number of Articles : 35 |
Description |
LPS responsive beige-like anchor protein |
| Gene Summary |
The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012] |
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