| Protein Name | decapping 2 |
|---|---|
| Organism | Arabidopsis thaliana |
| Gene ID | 831201 |
| Gene Symbol | DCP2 |
| UniProt | Q8GW31 (DCP2_ARATH), A0A654G0P1 (A0A654G0P1_ARATH) |
| Relationships |
Total Number of functionally related compound(s) :
6
Total Number of Articles : 2 |
Description |
decapping 2 |
| Gene Summary |
Encodes DCP2 with mRNA decapping activity. DCP2 forms a mRNA decapping complex with DCP1 (At1g08370) and VCS (VARICOSE) (At3g13300). Recombinant DCP2 is enzymatically active in vitro, generating from capped mRNAs m7GDP, and 5#Aeo-phosphorylated mRNAs. DCP1, DCP2 and VCS colocalize in cytoplasmic loci, which are putative Arabidopsis mRNA processing bodies. Null mutants of DCP1, DCP2, and VCS accumulate capped mRNAs with a reduced degradation rate. These mutants also share a similar lethal phenotype at the seedling cotyledon stage, with disorganized veins, swollen root hairs, and altered epidermal cell morphology. The protein was shown by immunoprecipitation not to interact with DCP1. |
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