| Protein Name | paired box 3 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 18505 |
| Gene Symbol | Pax3 |
| UniProt | P24610 (PAX3_MOUSE), Q8BRF1 (Q8BRF1_MOUSE), Q3TZM4 (Q3TZM4_MOUSE), Q3UGH9 (Q3UGH9_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
62
Total Number of Articles : 76 |
Description |
paired box 3 |
| Gene Summary |
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; chromatin binding activity; and transcription coregulator binding activity. Acts upstream of or within several processes, including nervous system development; regulation of somitogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; nose; and urinary system. Used to study Waardenburg syndrome; Waardenburg syndrome type 1; alveolar rhabdomyosarcoma; and neural tube defect. Human ortholog(s) of this gene implicated in Waardenburg syndrome; Waardenburg syndrome type 1; Waardenburg syndrome type 3; alveolar rhabdomyosarcoma; and craniofacial-deafness-hand syndrome. Orthologous to human PAX3 (paired box 3). [provided by Alliance of Genome Resources, Jun 2025] |
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