CPRiL

OTULIN

OTU deubiquitinase with linear linkage specificity

This gene encodes a member of the peptidase C65 family of ubiquitin isopeptidases. Members of this family remove ubiquitin from proteins. The encoded enzyme specifically recognizes and removes M1(Met1)-linked, or linear, ubiquitin chains from protein substrates. Linear ubiquitin chains are known to regulate the NF-kappa B signaling pathway in the context of immunity and inflammation. Mutations in this gene cause a potentially fatal autoinflammatory syndrome in human patients. [provided by RefSeq, Sep 2016]

• ubiquitin thioesterase otulin
• OTU domain-containing deubiquitinase with linear linkage specificity
• deubiquitinating enzyme otulin
family with sequence similarity 105, member B
ubiquitin thioesterase Gumby
AIPDS
AIPDSA
FAM105B
GUM
IMD107