| Protein Name | tryptophan 2,3-dioxygenase |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 6999 |
| Gene Symbol | TDO2 |
| UniProt | P48775 (T23O_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
275
Total Number of Articles : 352 |
Description |
tryptophan 2,3-dioxygenase |
| Gene Summary |
This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012] |
| synonyms |
|
| Properties | |