Protein Name PH domain and leucine rich repeat protein phosphatase 1
Organism Homo sapiens
Gene ID 23239
Gene Symbol

PHLPP1

UniProt O60346 (PHLP1_HUMAN)
Relationships Total Number of functionally related compound(s) : 61
Total Number of Articles : 58
Description

PH domain and leucine rich repeat protein phosphatase 1

Gene Summary

This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]

synonyms
  • PH domain leucine-rich repeat-containing protein phosphatase 1
  • PH domain-containing family E member 1
  • SCN circadian oscillatory protein
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Properties