Protein Name delta 4-desaturase, sphingolipid 1
Organism Mus musculus
Gene ID 13244
Gene Symbol

Degs1

UniProt O09005 (DEGS1_MOUSE)
Relationships Total Number of functionally related compound(s) : 21
Total Number of Articles : 21
Description

delta 4-desaturase, sphingolipid 1

Gene Summary

Enables retinol isomerase activity and sphingolipid delta-4 desaturase activity. Acts upstream of or within ceramide biosynthetic process and positive regulation of apoptotic process. Predicted to be located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human DEGS1 (delta 4-desaturase, sphingolipid 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • sphingolipid delta(4)-desaturase DES1
  • degenerative spermatocyte homolog 1
  • dihydroceramide desaturase
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Properties