Protein Name ssRNA exonuclease RAT1
Organism Saccharomyces cerevisiae S288C
Gene ID 854213
Gene Symbol

RAT1

UniProt Q02792 (XRN2_YEAST)
Relationships Total Number of functionally related compound(s) : 9
Total Number of Articles : 7
Description

ssRNA exonuclease RAT1

Gene Summary

Enables 5'-3' RNA exonuclease activity. Involved in RNA metabolic process and negative regulation of transcription elongation by RNA polymerase II. Acts upstream of or within mRNA splicing, via spliceosome. Located in nucleus. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma and lung cancer. Orthologous to human XRN2 (5'-3' exoribonuclease 2). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • ssRNA exonuclease RAT1
  • YOR048C
  • HKE1
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Properties