Protein Name | RNA binding fox-1 homolog 2 |
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Organism | Homo sapiens |
Gene ID | 23543 |
Gene Symbol | RBFOX2 |
UniProt | O43251 (RFOX2_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
71
Total Number of Articles : 63 |
Description |
RNA binding fox-1 homolog 2 |
Gene Summary |
This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
synonyms |
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Properties | |