Protein Name thyroid stimulating hormone subunit beta
Organism Homo sapiens
Gene ID 7252
Gene Symbol

TSHB

UniProt P01222 (TSHB_HUMAN)
Relationships Total Number of functionally related compound(s) : 52
Total Number of Articles : 50
Description

thyroid stimulating hormone subunit beta

Gene Summary

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

synonyms
  • thyrotropin subunit beta
  • thyroid stimulating hormone beta
  • thyrotropin beta chain
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Properties