| Protein Name | dishevelled |
|---|---|
| Organism | Drosophila melanogaster |
| Gene ID | 32078 |
| Gene Symbol | dsh |
| UniProt | P51140 (DSH_DROME) |
| Relationships |
Total Number of functionally related compound(s) :
20
Total Number of Articles : 22 |
Description |
dishevelled |
| Gene Summary |
Enables phosphatidic acid binding activity; protein domain specific binding activity; and signaling receptor complex adaptor activity. Involved in several processes, including morphogenesis of an epithelium; neuron differentiation; and positive regulation of cell projection organization. Located in apical cortex and plasma membrane. Part of Wnt signalosome. Is expressed in arista; dorsal-ventral compartment boundary of imaginal disc; egg chamber; imaginal disc; and organism. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in DiGeorge syndrome; autosomal dominant Robinow syndrome 2; autosomal dominant Robinow syndrome 3; and lung cancer. Orthologous to several human genes including DVL2 (dishevelled segment polarity protein 2) and DVL3 (dishevelled segment polarity protein 3). [provided by Alliance of Genome Resources, Jul 2025] |
| synonyms |
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| Properties | |