| Protein Name | cyclin-dependent kinase inhibitor 2A |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 25163 |
| Gene Symbol | Cdkn2a |
| UniProt | Q9R0Z3 (CDN2A_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
159
Total Number of Articles : 157 |
Description |
cyclin-dependent kinase inhibitor 2A |
| Gene Summary |
Predicted to enable several functions, including MDM2/MDM4 family protein binding activity; NF-kappaB binding activity; and enzyme inhibitor activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of hepatocyte proliferation; and nervous system development. Located in cytoplasm and nucleus. Used to study carcinoma (multiple); endometrial cancer; pre-malignant neoplasm; rhabdomyosarcoma; and sarcomatoid mesothelioma. Biomarker of hepatocellular carcinoma; hypertension; obesity; and osteoarthritis. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); hematologic cancer (multiple); melanoma (multiple); nervous system cancer (multiple); and pancreatic cancer (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A). [provided by Alliance of Genome Resources, Apr 2022] |
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