| Protein Name | cyclin dependent kinase inhibitor 2A |
|---|---|
| Organism | Mus musculus |
| Gene ID | 12578 |
| Gene Symbol | Cdkn2a |
| UniProt | Q64364 (ARF_MOUSE), P51480 (CDN2A_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
200
Total Number of Articles : 237 |
Description |
cyclin dependent kinase inhibitor 2A |
| Gene Summary |
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; MDM2/MDM4 family protein binding activity; and enzyme inhibitor activity. Involved in several processes, including negative regulation of lymphocyte proliferation; positive regulation of apoptotic process; and regulation of intracellular signal transduction. Acts upstream of or within several processes, including keratinocyte proliferation; negative regulation of mammary gland epithelial cell proliferation; and negative regulation of protein metabolic process. Located in cytoplasm and granular component. Part of protein-containing complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; immune system; and umbilical artery. Used to study high grade glioma; malignant peripheral nerve sheath tumor; melanoma (multiple); and pancreatic carcinoma (multiple). Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); high grade glioma (multiple); and melanoma (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A). [provided by Alliance of Genome Resources, Jul 2025] |
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