Protein Name estrogen receptor 1
Organism Rattus norvegicus
Gene ID 24890
Gene Symbol


UniProt P06211 (ESR1_RAT), D0FYH4 (D0FYH4_RAT), A0A0G2K0D4 (A0A0G2K0D4_RAT)
Relationships Total Number of functionally related compound(s) : 683
Total Number of Articles : 1218

estrogen receptor 1

Gene Summary

Enables several functions, including phosphatidylinositol 3-kinase regulatory subunit binding activity; promoter-specific chromatin binding activity; and transcription coactivator binding activity. Involved in several processes, including cellular response to lipid; regulation of neuron death; and reproductive structure development. Located in several cellular components, including T-tubule; perikaryon; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study several diseases, including Parkinsonism; infertility; obesity; pleurisy; and prostate disease (multiple). Biomarker of cryptorchidism; osteoporosis; and ovarian cancer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast cancer (multiple); type 2 diabetes mellitus; and vitiligo. Orthologous to human ESR1 (estrogen receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

  • estrogen receptor
  • C-terminally-truncated estrogen receptor alpha product-1
  • Er alpha
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