| Protein Name | afadin, adherens junction formation factor |
|---|---|
| Organism | Mus musculus |
| Gene ID | 17356 |
| Gene Symbol | Afdn |
| UniProt | Q9QZQ1 (AFAD_MOUSE), E9Q9C3 (E9Q9C3_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
12
Total Number of Articles : 11 |
Description |
afadin, adherens junction formation factor |
| Gene Summary |
Enables cell adhesion molecule binding activity. Involved in several processes, including cell-cell adhesion mediated by cadherin; pore complex assembly; and regulation of postsynapse assembly. Acts upstream of or within several processes, including adherens junction maintenance; nervous system development; and regulation of oligodendrocyte progenitor proliferation. Located in several cellular components, including adherens junction; apical junction complex; and apical part of cell. Part of pore complex. Is active in hippocampal mossy fiber to CA3 synapse; postsynaptic density membrane; and presynaptic active zone membrane. Is expressed in several structures, including central nervous system; embryo ectoderm; eye; genitourinary system; and tail bud. Orthologous to human AFDN (afadin, adherens junction formation factor). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |