| Protein Name | sine oculis-related homeobox 3 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 20473 |
| Gene Symbol | Six3 |
| UniProt | Q62233 (SIX3_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
2
Total Number of Articles : 2 |
Description |
sine oculis-related homeobox 3 |
| Gene Summary |
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and transcription corepressor binding activity. Involved in several processes, including camera-type eye development; forebrain development; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including forebrain development; lens induction in camera-type eye; and protein import into nucleus. Located in nucleus. Is expressed in several structures, including alimentary system; embryo ectoderm; limb; nervous system; and sensory organ. Used to study holoprosencephaly 2. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 2. Orthologous to human SIX3 (SIX homeobox 3). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |