CPRiL

Protein Name	NLR family, pyrin domain containing 1A
Organism	Mus musculus
Gene ID	195046
Gene Symbol	Nlrp1a
UniProt	Q2LKU9 (NLR1A_MOUSE)
Relationships	Total Number of functionally related compound(s) : 192 Total Number of Articles : 242
Description	NLR family, pyrin domain containing 1A
Gene Summary	Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and cysteine-type endopeptidase activator activity. Involved in positive regulation of interleukin-1 beta production and response to muramyl dipeptide. Acts upstream of or within defense response to bacterium and programmed necrotic cell death. Predicted to be located in neuronal cell body and nucleoplasm. Predicted to be part of NLRP1 inflammasome complex and NLRP3 inflammasome complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human NLRP1 (NLR family pyrin domain containing 1). [provided by Alliance of Genome Resources, Jun 2025]
synonyms	NACHT, LRR and PYD domains-containing protein 1a NACHT, LRR and PYD containing protein 1 NACHT, leucine rich repeat and PYD containing 1 NACHT/LRR/pyrin domain-containing protein 1 NLR family, pyrin domain containing 1 NLR family, pyrin domain containing 1A, CAST/EiJ strain specific NLR family, pyrin domain containing 1A, PWK/PhJ strain specific NLR family, pyrin domain containing 1A, WSB/EiJ strain specific caspase recruitment domain protein caspase recruitment domain-containing protein 7 death effector filament-forming Ced-4-like apoptosis protein nucleotide-binding domain and caspase recruitment domain CARD7 DEFCAP Gm14 Gm15 NAC Nalp1 Nalp1a Nlrp1 PP1044 Click to show/hide the synonyms
Properties