| Protein Name | APC, WNT signaling pathway regulator |
|---|---|
| Organism | Mus musculus |
| Gene ID | 11789 |
| Gene Symbol | Apc |
| UniProt | B2RUG9 (B2RUG9_MOUSE), Q8BNP7 (Q8BNP7_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
175
Total Number of Articles : 181 |
Description |
APC, WNT signaling pathway regulator |
| Gene Summary |
Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and enzyme binding activity. Involved in insulin receptor signaling pathway; positive regulation of cold-induced thermogenesis; and positive regulation of protein localization to centrosome. Acts upstream of or within several processes, including negative regulation of epithelial cell proliferation; regionalization; and regulation of apoptotic process. Located in several cellular components, including axonal growth cone; cell projection membrane; and microtubule cytoskeleton. Part of Scrib-APC-beta-catenin complex. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and peripheral nervous system ganglion. Used to study breast cancer; familial adenomatous polyposis; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial adenomatous polyposis 1; gastrointestinal system cancer (multiple); hereditary desmoid disease; and reproductive organ cancer (multiple). Orthologous to human APC (APC regulator of WNT signaling pathway). [provided by Alliance of Genome Resources, Jun 2025] |
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