Protein Name sodium voltage-gated channel alpha subunit 11
Organism Homo sapiens
Gene ID 11280
Gene Symbol

SCN11A

UniProt Q9UI33 (SCNBA_HUMAN), A0A6Q8PGY3 (A0A6Q8PGY3_HUMAN)
Relationships Total Number of functionally related compound(s) : 334
Total Number of Articles : 400
Description

sodium voltage-gated channel alpha subunit 11

Gene Summary

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is highly expressed in nociceptive neurons of dorsal root ganglia and trigeminal ganglia. It mediates brain-derived neurotrophic factor-evoked membrane depolarization and is a major effector of peripheral inflammatory pain hypersensitivity. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy type VII and familial episodic pain syndrome-3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]

synonyms
  • sodium channel protein type 11 subunit alpha
  • peripheral nerve sodium channel 5
  • sensory neuron sodium channel 2
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Properties