| Protein Name | dihydropyrimidine dehydrogenase |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 81656 |
| Gene Symbol | Dpyd |
| UniProt | O89000 (DPYD_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
43
Total Number of Articles : 39 |
Description |
dihydropyrimidine dehydrogenase |
| Gene Summary |
Enables several functions, including nucleotide binding activity; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; and protein homodimerization activity. Involved in several processes, including pyrimidine nucleobase metabolic process; response to glucocorticoid; and response to nutrient. Located in cytosol. Used to study colorectal cancer. Biomarker of liver disease. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022] |
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| Properties | |