Protein Name serine peptidase inhibitor Kazal type 1
Organism Homo sapiens
Gene ID 6690
Gene Symbol

SPINK1

UniProt P00995 (ISK1_HUMAN)
Relationships Total Number of functionally related compound(s) : 218
Total Number of Articles : 199
Description

serine peptidase inhibitor Kazal type 1

Gene Summary

The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008]

synonyms
  • serine protease inhibitor Kazal-type 1
  • pancreatic secretory trypsin inhibitor
  • serine protease inhibitor, Kazal type 1
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Properties