Protein Name histidine rich glycoprotein
Organism Homo sapiens
Gene ID 3273
Gene Symbol


UniProt P04196 (HRG_HUMAN)
Relationships Total Number of functionally related compound(s) : 133
Total Number of Articles : 122

histidine rich glycoprotein

Gene Summary

This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. The encoded protein also has a peptide that displays antimicrobial activity against C. albicans, E. coli, S. aureus, P. aeruginosa, and E. faecalis. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Nov 2014]

  • histidine-rich glycoprotein
  • histidine-proline-rich glycoprotein
  • HPRG
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