Protein Name TOP6B like initiator of meiotic double strand breaks
Organism Mus musculus
Gene ID 381196
Gene Symbol

Top6bl

UniProt A0A182DWE7 (A0A182DWE7_MOUSE)
Relationships Total Number of functionally related compound(s) : 1
Total Number of Articles : 1
Description

TOP6B like initiator of meiotic double strand breaks

Gene Summary

Predicted to enable DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Involved in meiotic DNA double-strand break formation and reciprocal meiotic recombination. Predicted to be located in chromosome. Is expressed in ovary; primary oocyte; secondary oocyte; and testis. Human ortholog(s) of this gene implicated in gestational trophoblastic neoplasm. Orthologous to human TOP6BL (TOP6B like initiator of meiotic double strand breaks). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • type 2 DNA topoisomerase 6 subunit B-like
  • type 2 DNA topoisomerase VI subunit B-like
  • Gm960
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Properties