Protein Name Rho guanine nucleotide exchange factor 26
Organism Homo sapiens
Gene ID 26084
Gene Symbol

ARHGEF26

UniProt Q96DR7 (ARHGQ_HUMAN), B3KXG0 (B3KXG0_HUMAN), A0A140VJU4 (A0A140VJU4_HUMAN)
Relationships Total Number of functionally related compound(s) : 9
Total Number of Articles : 8
Description

Rho guanine nucleotide exchange factor 26

Gene Summary

This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

synonyms
  • rho guanine nucleotide exchange factor 26
  • Rho guanine nucleotide exchange factor (GEF) 26
  • SH3 domain-containing guanine exchange factor
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Properties