| Protein Name | histone deacetylase 3 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 8841 |
| Gene Symbol | HDAC3 |
| UniProt | O15379 (HDAC3_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
245
Total Number of Articles : 283 |
Description |
histone deacetylase 3 |
| Gene Summary |
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008] |
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