Protein Name histone deacetylase 3
Organism Homo sapiens
Gene ID 8841
Gene Symbol


UniProt O15379 (HDAC3_HUMAN)
Relationships Total Number of functionally related compound(s) : 245
Total Number of Articles : 283

histone deacetylase 3

Gene Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]

  • histone deacetylase 3
  • SMAP45
  • protein deacetylase HDAC3
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