Protein Name CD46 molecule
Organism Homo sapiens
Gene ID 4179
Gene Symbol


UniProt P15529 (MCP_HUMAN)
Relationships Total Number of functionally related compound(s) : 415
Total Number of Articles : 346

CD46 molecule

Gene Summary

The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]

  • membrane cofactor protein
  • CD46 antigen, complement regulatory protein
  • CD46 molecule, complement regulatory protein
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