Protein Name calcium voltage-gated channel subunit alpha1 B
Organism Homo sapiens
Gene ID 774
Gene Symbol

CACNA1B

UniProt Q00975 (CAC1B_HUMAN)
Relationships Total Number of functionally related compound(s) : 157
Total Number of Articles : 145
Description

calcium voltage-gated channel subunit alpha1 B

Gene Summary

The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

synonyms
  • voltage-dependent N-type calcium channel subunit alpha-1B
  • Cav2.2 voltage-gated Ca2+ channel
  • brain calcium channel III
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Properties