| Protein Name | keratin 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 16678 |
| Gene Symbol | Krt1 |
| UniProt | P04104 (K2C1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
59
Total Number of Articles : 47 |
Description |
keratin 1 |
| Gene Summary |
Predicted to enable carbohydrate binding activity and protein heterodimerization activity. Predicted to be a structural constituent of skin epidermis. Acts upstream of or within establishment of skin barrier and negative regulation of inflammatory response. Located in keratin filament. Is active in cornified envelope. Is expressed in autopod; nose; skin; and tongue. Used to study epidermolytic hyperkeratosis. Human ortholog(s) of this gene implicated in KRT1-related nonepidermolytic palmoplantar keratoderma; epidermolytic hyperkeratosis; epidermolytic hyperkeratosis 1; epidermolytic palmoplantar keratoderma 2; and keratosis palmoplantaris striata 3. Orthologous to human KRT1 (keratin 1). [provided by Alliance of Genome Resources, Jul 2025] |
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