| Protein Name | topoisomerase (DNA) II binding protein 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 235559 |
| Gene Symbol | Topbp1 |
| UniProt | Q6ZQF0 (TOPB1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
6
Total Number of Articles : 5 |
Description |
topoisomerase (DNA) II binding protein 1 |
| Gene Summary |
Predicted to enable several functions, including identical protein binding activity; phosphorylation-dependent protein binding activity; and protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including broken chromosome clustering; double-strand break repair; and mitotic G2/M transition checkpoint. Predicted to act upstream of or within DNA damage checkpoint signaling; double-strand break repair; and reciprocal meiotic recombination. Located in condensed nuclear chromosome and male germ cell nucleus. Is expressed in cerebral cortex ventricular layer; embryo; and metanephros. Orthologous to human TOPBP1 (DNA topoisomerase II binding protein 1). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |