| Protein Name | excision repair cross-complementing rodent repair deficiency, complementation group 6 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 319955 |
| Gene Symbol | Ercc6 |
| UniProt | F8VPZ5 (ERCC6_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
42
Total Number of Articles : 30 |
Description |
excision repair cross-complementing rodent repair deficiency, complementation group 6 |
| Gene Summary |
Predicted to enable several functions, including ATP binding activity; ATP-dependent activity, acting on DNA; and protein tyrosine kinase activator activity. Acts upstream of or within several processes, including DNA repair; intracellular signal transduction; and photoreceptor cell maintenance. Predicted to be located in nuclear body; nucleolus; and site of DNA damage. Predicted to be part of B-WICH complex and transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in genitourinary system. Used to study Cockayne syndrome. Human ortholog(s) of this gene implicated in several diseases, including Cockayne syndrome (multiple); De Sanctis-Cacchione syndrome; UV-sensitive syndrome; gastrointestinal system cancer (multiple); and respiratory system cancer (multiple). Orthologous to human ERCC6 (ERCC excision repair 6, chromatin remodeling factor). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |