Protein Name excision repair cross-complementing rodent repair deficiency, complementation group 6
Organism Mus musculus
Gene ID 319955
Gene Symbol

Ercc6

UniProt F8VPZ5 (ERCC6_MOUSE)
Relationships Total Number of functionally related compound(s) : 42
Total Number of Articles : 30
Description

excision repair cross-complementing rodent repair deficiency, complementation group 6

Gene Summary

Predicted to enable several functions, including ATP binding activity; protein C-terminus binding activity; and protein tyrosine kinase activator activity. Acts upstream of or within several processes, including intracellular signal transduction; nucleic acid metabolic process; and photoreceptor cell maintenance. Predicted to be located in nuclear body; nucleolus; and site of DNA damage. Predicted to be part of transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in genitourinary system. Used to study Cockayne syndrome. Human ortholog(s) of this gene implicated in several diseases, including Cockayne syndrome (multiple); De Sanctis-Cacchione syndrome; UV-sensitive syndrome; age related macular degeneration 5; and primary ovarian insufficiency 11. Orthologous to human ERCC6 (ERCC excision repair 6, chromatin remodeling factor). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • DNA excision repair protein ERCC-6
  • ATP-dependent helicase ERCC6
  • CS group B correcting
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Properties