Protein Name plasminogen activator, tissue type
Organism Rattus norvegicus
Gene ID 25692
Gene Symbol

Plat

UniProt P19637 (TPA_RAT)
Relationships Total Number of functionally related compound(s) : 385
Total Number of Articles : 361
Description

plasminogen activator, tissue type

Gene Summary

Predicted to enable phosphoprotein binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; positive regulation of ovulation; and prevention of polyspermy. Located in cytoplasm; extracellular space; and synapse. Is active in several cellular components, including glutamatergic synapse; neuronal dense core vesicle; and perisynaptic space. Used to study disseminated intravascular coagulation and status epilepticus. Biomarker of brain edema; middle cerebral artery infarction; sciatic neuropathy; transient cerebral ischemia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; factor VIII deficiency; osteonecrosis; and thrombophilia due to decreased release of PLAT. Orthologous to human PLAT (plasminogen activator, tissue type). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • tissue-type plasminogen activator
  • t-PA
  • t-plasminogen activator
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Properties