| Protein Name | plasminogen activator, tissue type |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 25692 |
| Gene Symbol | Plat |
| UniProt | P19637 (TPA_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
385
Total Number of Articles : 361 |
Description |
plasminogen activator, tissue type |
| Gene Summary |
Predicted to enable phosphoprotein binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to gonadotropin stimulus; and plasminogen activation. Located in extracellular space. Is active in several cellular components, including glutamatergic synapse; neuronal dense core vesicle; and perisynaptic space. Used to study disseminated intravascular coagulation and status epilepticus. Biomarker of brain edema; middle cerebral artery infarction; sciatic neuropathy; transient cerebral ischemia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; hemophilia (multiple); osteonecrosis; and type 2 diabetes mellitus. Orthologous to human PLAT (plasminogen activator, tissue type). [provided by Alliance of Genome Resources, Jul 2025] |
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