| Protein Name | azurocidin 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 566 |
| Gene Symbol | AZU1 |
| UniProt | P20160 (CAP7_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
124
Total Number of Articles : 103 |
Description |
azurocidin 1 |
| Gene Summary |
Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Nov 2015] |
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| Properties | |