| Protein Name | pyruvate dehydrogenase E1 subunit beta |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 5162 |
| Gene Symbol | PDHB |
| UniProt | P11177 (ODPB_HUMAN), A0A384MDR8 (A0A384MDR8_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
20
Total Number of Articles : 20 |
Description |
pyruvate dehydrogenase E1 subunit beta |
| Gene Summary |
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2012] |
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| Properties | |