Protein Name ADAM metallopeptidase with thrombospondin type 1 motif 1
Organism Mus musculus
Gene ID 11504
Gene Symbol

Adamts1

UniProt P97857 (ATS1_MOUSE), Q3TQF7 (Q3TQF7_MOUSE), Q3TTE6 (Q3TTE6_MOUSE)
Relationships Total Number of functionally related compound(s) : 26
Total Number of Articles : 26
Description

ADAM metallopeptidase with thrombospondin type 1 motif 1

Gene Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family and preproprotein that is proteolytically processed to generate a mature protein product. This secreted protein product plays an important role in ovulation, likely through its cleavage of the extracellular matrix component versican. The encoded protein may enhance tumorigenesis in a mouse model of breast cancer. Homozygous knockout mice for this gene exhibit enhanced perinatal lethality, impaired growth and adipose tissue development, and impaired ovulation in females. [provided by RefSeq, Oct 2015]

synonyms
  • A disintegrin and metalloproteinase with thrombospondin motifs 1
  • ADAM-TS 1
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
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Properties