Protein Name peptidyl arginine deiminase 1
Organism Homo sapiens
Gene ID 29943
Gene Symbol


Relationships Total Number of functionally related compound(s) : 557
Total Number of Articles : 406

peptidyl arginine deiminase 1

Gene Summary

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

  • protein-arginine deiminase type-1
  • hPAD-colony 10
  • peptidyl arginine deiminase, type I
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