Protein Name major histocompatibility complex, class I, G
Organism Homo sapiens
Gene ID 3135
Gene Symbol

HLA-G

UniProt P17693 (HLAG_HUMAN), Q6DU14 (Q6DU14_HUMAN), Q31611 (Q31611_HUMAN)
Relationships Total Number of functionally related compound(s) : 148
Total Number of Articles : 204
Description

major histocompatibility complex, class I, G

Gene Summary

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

synonyms
  • HLA class I histocompatibility antigen, alpha chain G
  • HLA G antigen
  • HLA-G histocompatibility antigen, class I, G
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Properties