Protein Name elastin
Organism Homo sapiens
Gene ID 2006
Gene Symbol


UniProt P15502 (ELN_HUMAN), B3KRT8 (B3KRT8_HUMAN), G5E950 (G5E950_HUMAN), G3V0G6 (G3V0G6_HUMAN), E7ENM0 (E7ENM0_HUMAN), E7EN65 (E7EN65_HUMAN), Q59H17 (Q59H17_HUMAN), Q8NBI4 (Q8NBI4_HUMAN), Q6ZUN2 (Q6ZUN2_HUMAN), B4E3S4 (B4E3S4_HUMAN)
Relationships Total Number of functionally related compound(s) : 856
Total Number of Articles : 1448


Gene Summary

This gene encodes a protein that is one of the two components of elastic fibers. Elastic fibers comprise part of the extracellular matrix and confer elasticity to organs and tissues including the heart, skin, lungs, ligaments, and blood vessels. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Degradation products of the encoded protein, known as elastin-derived peptides or elastokines, bind the elastin receptor complex and other receptors and stimulate migration and proliferation of monocytes and skin fibroblasts. Elastokines can also contribute to cancer progression. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. [provided by RefSeq, Aug 2017]

  • elastin
  • tropoelastin
  • ADCL1
Click to show/hide the synonyms