| Protein Name | WD repeat domain 11 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 55717 |
| Gene Symbol | WDR11 |
| UniProt | Q9BZH6 (WDR11_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
14
Total Number of Articles : 10 |
Description |
WD repeat domain 11 |
| Gene Summary |
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008] |
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