Protein Name eukaryotic translation initiation factor 2B subunit alpha
Organism Rattus norvegicus
Gene ID 64514
Gene Symbol

Eif2b1

UniProt Q64270 (EI2BA_RAT)
Relationships Total Number of functionally related compound(s) : 5
Total Number of Articles : 6
Description

eukaryotic translation initiation factor 2B subunit alpha

Gene Summary

Enables GDP binding activity; GTP binding activity; and translation initiation factor activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including negative regulation of guanyl-nucleotide exchange factor activity; response to amino acid starvation; and response to glucose. Part of eukaryotic translation initiation factor 2 complex and eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 1. Orthologous to human EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • translation initiation factor eIF2B subunit alpha
  • GTP-exchange protein
  • eIF-2B GDP-GTP exchange factor subunit alpha
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Properties