| Protein Name | seven up |
|---|---|
| Organism | Drosophila melanogaster |
| Gene ID | 41491 |
| Gene Symbol | svp |
| UniProt | P16375 (7UP1_DROME), P16376 (7UP2_DROME), A0A0B4KFQ2 (A0A0B4KFQ2_DROME) |
| Relationships |
Total Number of functionally related compound(s) :
3
Total Number of Articles : 4 |
Description |
seven up |
| Gene Summary |
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including cardioblast cell fate determination; epithelial cell proliferation involved in Malpighian tubule morphogenesis; and neurogenesis. Located in cytoplasm. Is expressed in several structures, including apterous-expressing neuron of the lateral cluster of the thorax; dorsal vessel wall cell; glial cell; neuroblasts; and photoreceptor neurons. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in 46,XX sex reversal 5 and Bosch-Boonstra-Schaaf optic atrophy syndrome. Orthologous to several human genes including NR2F2 (nuclear receptor subfamily 2 group F member 2). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |