| Protein Name | potassium voltage-gated channel subfamily A member 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 3736 |
| Gene Symbol | KCNA1 |
| UniProt | Q09470 (KCNA1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
152
Total Number of Articles : 136 |
Description |
potassium voltage-gated channel subfamily A member 1 |
| Gene Summary |
This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008] |
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| Properties | |