| Protein Name | excision repair cross-complementing rodent repair deficiency, complementation group 4 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 50505 |
| Gene Symbol | Ercc4 |
| UniProt | Q9QZD4 (XPF_MOUSE), Q3UEU6 (Q3UEU6_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
9
Total Number of Articles : 9 |
Description |
excision repair cross-complementing rodent repair deficiency, complementation group 4 |
| Gene Summary |
Enables TFIID-class transcription factor complex binding activity and promoter-specific chromatin binding activity. Acts upstream of or within DNA repair; UV protection; and regulation of autophagy. Predicted to be located in chromosome, telomeric region and nucleus. Predicted to be part of ERCC4-ERCC1 complex and nucleotide-excision repair factor 1 complex. Is expressed in central nervous system and retina. Used to study xeroderma pigmentosum group F. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group Q; XFE progeroid syndrome; pancreatic cancer; polyneuropathy due to drug; and xeroderma pigmentosum (multiple). Orthologous to human ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit). [provided by Alliance of Genome Resources, Jul 2025] |
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