| Protein Name | mitogen activated protein kinase kinase 4 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 287398 |
| Gene Symbol | Map2k4 |
| UniProt | Q4KSH6 (Q4KSH6_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
39
Total Number of Articles : 27 |
Description |
mitogen activated protein kinase kinase 4 |
| Gene Summary |
Enables JUN kinase kinase activity. Involved in several processes, including cellular response to sorbitol; positive regulation of JNK cascade; and positive regulation of macromolecule metabolic process. Located in axon; dendrite cytoplasm; and perikaryon. Used to study transient cerebral ischemia. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian serous carcinoma; pancreatic cancer; respiratory system cancer (multiple); and urinary bladder cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4). [provided by Alliance of Genome Resources, Jul 2025] |
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