Protein Name SH2B adaptor protein 2
Organism Homo sapiens
Gene ID 10603
Gene Symbol

SH2B2

UniProt O14492 (SH2B2_HUMAN)
Relationships Total Number of functionally related compound(s) : 33
Total Number of Articles : 28
Description

SH2B adaptor protein 2

Gene Summary

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]

synonyms
  • SH2B adapter protein 2
  • SH2 and PH domain-containing adapter protein APS
  • adapter protein with pleckstrin homology and Src homology 2 domains
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Properties