Protein Name ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Organism Homo sapiens
Gene ID 116984
Gene Symbol

ARAP2

UniProt Q8WZ64 (ARAP2_HUMAN), A7E2A5 (A7E2A5_HUMAN)
Relationships Total Number of functionally related compound(s) : 3
Total Number of Articles : 3
Description

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

Gene Summary

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]

synonyms
  • arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
  • Arf and Rho GAP adapter protein 2
  • centaurin-delta-1
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Properties