Protein Name | glycine decarboxylase |
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Organism | Homo sapiens |
Gene ID | 2731 |
Gene Symbol | GLDC |
UniProt | P23378 (GCSP_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
119
Total Number of Articles : 97 |
Description |
glycine decarboxylase |
Gene Summary |
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010] |
synonyms |
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Properties | |