Protein Name glycine decarboxylase
Organism Homo sapiens
Gene ID 2731
Gene Symbol


UniProt P23378 (GCSP_HUMAN)
Relationships Total Number of functionally related compound(s) : 119
Total Number of Articles : 97

glycine decarboxylase

Gene Summary

Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]

  • glycine dehydrogenase (decarboxylating), mitochondrial
  • glycine cleavage system protein P
  • glycine decarboxylase P-protein
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